The subjects judged the cosmetic properties of the products positively. Furthermore, the data provide evidence for the suitability of this three-product Thiamidol regimen for day-to-day life. FOIA -. 8600 Rockville Pike Ltude en situation relle avec un rgime de soins du visage typique contenant du Thiamidol montre une amlioration de lhyperpigmentation faciale et confirme la tolrance. There isnt any measure of how much benzene is safe to include in sun-care products, though; the FDA established a temporary 2 ppm limit on hand sanitizers during the pandemic, but there is no analogue for SPF. Thiamidol works differently than various acids or retinol products used for hyperpigmentation: while those ususally promote a quicker cell turnover, Thiamidol promises to minimise the production of melanin that'll turn into hyperpigmentation. :( I would love to try it. Peuckmann V, Fisch M, Bruera E "Potential novel uses of thalidomide - Focus on palliative care." Detection of benzene is not a commonly performed test on sunscreens as they are brought to the market, Dr. Zeichner explains. shakiness in the legs, arms, hands, or feet. Thiamidol is an effective and patented ingredient that acts at the root cause of hyperpigmentation and is clinically . Thalidomide distribution is restricted through the THALOMID REMS(TM) program (formerly known as the S.T.E.P.S. program). After the area/s is healed from treatment, it is very important to use a sunscreen DAILY to all areas of exposed skin. sores, ulcers, or white spots in the mouth or on the lips. 10.3390/ijms19092668 A health condition and/or pre-existing or dormant dermatologic disease on the face (e.g., psoriasis, rosacea . There are two things to consider here, which kind of seem to cancel each other out: normally, one study researching the effectiveness of one patented ingredient done by the company that holds the patent doesn't quite inspire a lot of confidence. In fact, respondents in our studies report that the products not only improved their lives and provided relief, but also have the highest efficacy against post-acne marks of any products they have ever tried. The Definition of Cancer. Btw, I just realised I didn't put the actual name of the product in the post. So if you inhibit Tyrosinase, you won't produce as much Melanin, so your skin will get lighter. Anti-Pigment Dual Serum for all skin types. Clipboard, Search History, and several other advanced features are temporarily unavailable. Cancer can start almost anywhere in the human body, which is made up of trillions of cells. and transmitted securely. (b) Melanin index scores of lesional and perilesional skin after 4, 8 and 12weeks of treatment. I would have thought you'd be better with the specific toner no? Hamnvik OP, Larsen PR, Marqusee E "Thyroid dysfunction from antineoplastic agents." Within 12 weeks of using Eucerin Anti-Pigment Dual Serum, hyperpigmentation reduction of up to 75% was shown. Thiamidol is a revolutionary and unique active ingredient that reduces the dark marks and pigment spots also known as hyperpigmentation, a common skin concern. It has definitely lightened up my spots significantly. Johnson & Johnson (the maker of Neutrogena sunscreen), Sun Bum, and CVS all denied including benzene in their products in statements to CBS News. Am. Kang, W.H. The split-face study was double-blind, randomized, controlled, including two Thiamidol containing products (serum and day care SPF 30). We may earn commission from links on this page, but we only recommend products we back. Conclusion: -, Del Bino S., Duval C., Bernerd F.. Clinical and biological characterization of skin pigmentation diversity and its consequences on UV impact. Hard to believe since hyperpigmentation is such a common and hard to tackle issue! Cancer occurs from environmental exposures to these cells over time. Aquaphor can be greasy and difficult to apply evenly. A Narrative Review. Here's the before and after photo from the study. I just received my Eucerin anti pigment night cream and serum today, applied for first time tonight. Melasma, also known as chloasma, is a form of hyperpigmentation that appears on the face, especially on the cheeks, bridge of the nose, forehead and upper lip and sometimes on other sun-exposed parts of the body, such as the forearms.Men can experience melasma, but it is much more common in women. stomach cramps. Since then, independent researchers across the globe have confirmed . I'll try this stuff out once I'll be sure the azelaic acid wont work. Selfassessment of hyperpigmentation by modified Griffiths score (09) in the splitface study. It usually occurs after the first dose of a drug and within 24 hours of taking the drug and exposure to the sun. These dark marks and pigment spots on the skin are quite common but can be distressing when noticeable. However, products containing Thiamidol should only be applied a maximum of four times per day. Hearst Magazine Media, Inc. All Rights Reserved. Independent studies are how we know something actually works. Search for: Close search Isobutylamido thiazolyl resorcinol for prevention of UVB-induced hyperpigmentation. . Clin Exp Rheumatol 11 (1993): 487-93, 5. Feaver AA, McCune DE, Mysliwiec AG, Mysliwiec V "Thalidomide-induced organizing pneumonia." Selected digital images of two subjects before and after treatment with the combination (serum, day care SPF30) during the splitface study. Will keep you all updated! PMC However, it apparently stands to reason that they would want their testing to be done by their own people, to prevent industrial espionage. Natural options for management of melasma, a review. There are many causes of cancer, and some are preventable. Melasma can be refractory to treatment, and relapses are frequent. I'd be really interested to hear your thoughts on this study! Based on our research, we rate FALSE the claim that cancer increased twentyfold among the COVID-19 vaccinated due to suppressed T cells. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Eucerin Anti-Pigment Dual Face Serum for Pigmentation & Dark Spots with Thiamidol & Hyaluronic Acid 30ml. Eucerin Anti-Pigment Dual Serum contains two separate serums within the same bottle, those being Thiamidol and Hyaluronic Acid. The https:// ensures that you are connecting to the Offer. A key focus of Beiersdorf's research once again in 2018 was on further study of the mitochondrial . Sohlbach K, Heinze S, Shiratori K, Sure U, Pagenstecher A, Neubauer A "Encephalopathy in a patient after long-term treatment with thalidomide." Valisure contends that benzene should not be allowed in any SPF products, and part of their petition asks the FDA to establish a concentration limit for products like sunscreens, on top of a daily exposure limit. Its the result of 10 years of research and over 50,000 tested ingredients, and you can find it as a key ingredient in many of our skincare products. What causes drug-induced photosensitivity? It can also inflame and damage the inner layer of the stomach. I know, it's very interesting! Do you use a strong sun block in your routine? Sunscreen is one of the most effective tools we have against the suns damaging UV rays, shielding us from annoying and dangerous skin issues, including skin cancer. Epub 2020 Sep 4. Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. Selfassessment by modified Griffiths score (110) at each time point for evenness, radiance and smoothness from all subjects considered for evaluation in the realworld study (meanSD, Changes of mMASI scores (meanSD) from baseline to week 4 (1.32.0), week 8 (2.82.9) and week 12 (4.93.0) (. N Engl J Med 341 (1999): 1565-71, 6. Advances in Biomedical Functions of Natural Whitening Substances in the Treatment of Skin Pigmentation Diseases. Tap into the revitalizing magic of vitamin C serum enriched with hyaluronic acid. Besides- as it's quite a new ingredient- I can't find which products are incompatible with it. It's kind of expensive to import. The effect of skin care formulations containing Thiamidol on acne-related PIH was investigated in two studies, a vehicle-controlled, double-blinded, randomized clinical study and a clinical observational study. To examine the in vivo efficacy of thiamidol, a clinical study was also carried out. does aquaphor protect from sun. While it was not initially in the formula, it was created through a chemical reaction.. Johnson & Johnson is now recalling five Neutrogena and Aveeno SPF lines over benzene contamination. It is also one of the leading causes of death . Exercise during cancer treatment may improve physical and mental health while also reducing treatment-related side effects. -, Nomakhosi, M. and Heidi, A. Thalomid (thalidomide)." Cause Related Marketing; This is your opportunity to help create a world immune to cancer. Epub 2021 Oct 21. For over 100 years, we have dedicated ourselves to researching and innovating in the field of skin science. Freckles are harmless concentrations of melanin that cause dark spots on the skin. Freckles are flat small tan or light-brown spots on sun-exposed skin. Its used in plastic production and appears in gasoline and cigarette smoke. Lauto-valuation des sujets a dmontr que le Thiamidol amliorait significativement la visibilit de lhyperpigmentation induite par lacn par rapport au traitement par vhicule. Although these findings sound concerning, they dont prove that every product from these brands are always chock-full of benzine: There was significant variability from batch to batch, even within a single brand, the report states. It develops in squamous cells, which are the thin, flat cells that make up the outermost layer of your skin . Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Everyone is welcome in this community; remember to be kind and assume good faith :). Epub 2022 Mar 8. Les deux tudes avaient une dure de 3 mois et comportaient des valuations telles que la photographie mdicale, lvaluation par les mdecins et les mesures de lindice de mlanine. government site. Lump or area of thickening that can be felt under the skin. 2022 Sep 24;19(19):12084. doi: 10.3390/ijerph191912084. 2022 May;314(4):357-361. doi: 10.1007/s00403-021-02239-6. "Thalidomide- and lenalidomide-associated thromboembolism among patients with cancer." Horowitz SB, Stirling AL "Thalidomide-induced toxic epidermal necrolysis." But there is no good evidence that lycopene reduces overall cancer risk or the risk of prostate cancer. Epub 2018 Feb 7. It went on nicely, didn't leave a greasy/sticky film, had no smell and didn't cause any irritation. Thiamidol is currently the most effective inhibitor of human tyrosinase, the enzyme that contributes to skin hyperpigmentation. Unable to load your collection due to an error, Unable to load your delegates due to an error, Treatment of experimentally induced suction blister PIH. Yes, there could be health issues linked to benzene in sunscreen, but they havent been established yet. These studies focused on a chemical in tomatoes called lycopene. If thiamidol is a more effective ingredient I would consider adding it to my regimen. 9. Stubborn melasma has no chances with it. Some get . The serum was applied twice daily on one half of the face and the day care SPF30 twice-daily on the whole face. I'm bummed I only bought 1 bottle. The descriptive term, benign keratosis, is . Objective. Thiamidol was the most potent inhibitor of human tyrosinase out of 50 000 screened substances. Please enable it to take advantage of the complete set of features! "Product Information. METHODS The investigators are conducting a research to study an efficacy and tolerability of Isobutylamido-thiazolyl-resorcinol 0.2% in lightening of the facial hyperpigmentation in comparison to vehicle intervention in 4, 8 and 12-week period. Hamadani M, Benson DM Jr, Copelan EA "Thalidomide-induced fulminant hepatic failure." Delivery in 8-10 daysDelivery in 6-15 daysDelivery in 7-10 daysDelivery in 9-11 daysDelivery in 12-14 daysDelivery in 8-10 daysDelivery in 4-7 days Arrowitz C, Schoelermann AM, Mann T, Jiang LI, Weber T, Kolbe L. J Invest Dermatol. -, Maymone, M.B.C. Subjects rated the efficacy of the Thiamidol formulation significantly better with regard to overall decreased intensity of dark spots and their overall appearance throughout the study. Stress, meanwhile, may lead to high blood pressure, and beta blockers to treat high blood pressure may cause fatigue. This was the first step in identifying tyrosinases targeted structure. Bookshelf We are investigating the cause of this issue, which is limited to certain aerosol sunscreen products.. So I stumbled upon this post after picking up a thiamidol cream in London while on vacation a month ago. Taylor S., Grimes P., Lim J., Im S., Lui H., Postinflammatory hyperpigmentation. Symptoms. Eight weeks of regular usage twice a day. The objective of this research was to investigate the potential of this compound to prevent PIH induced by epidermal wounding (suction blister) and related to acne. 8600 Rockville Pike An official website of the United States government. Selected digital images of two subjects before and after treatment with the combination, Clinical grading scores (04) from the splitface study ( n = 34) showing, Selfassessment of hyperpigmentation by modified, Selfassessment of hyperpigmentation by modified Griffiths score (09) in the splitface study. According to cosmetic dermatologist Michele Green, MD, melasma is a skin condition that causes patches of dark discoloration on the skin. 2021 Mar;20(3):987-992. doi: 10.1111/jocd.13615. Drugs 60 (2000): 273-92, 7. Federal government websites often end in .gov or .mil. RSULTATS: Aprs 2 semaines de traitement seulement, les sites de bulles de succion traits par du Thiamidol taient significativement plus clairs que les sites-tmoins et avaient montr une amlioration tout au long de la priode de traitement. Thiamidol is a new potent tyrosinase inhibitor that has been found effective as a cosmeceutical for the depigmenting of melasma. Weight changes, including unintended loss or gain. Significant differences are marked in comparison to vehicle (, Treatment with a skin care regimen of three Thiamidolcontaining products. Most people who get rosacea are: Between 30 and 50 years of age. (a) Representative images of subjects with acneinduced PIH at baseline and after 4, 8 and 12weeks of treatment with the Thiamidolcontaining formulation (verum) or the vehicle. Some general signs and symptoms associated with, but not specific to, cancer, include: Fatigue. In vivo, it was well tolerated and improved melasma significantly. Retinoid or Retinol and Vitamin C. Here's the theme: Use retinoids wisely. Fox MR, Harris A "Intractable insomnia after cessation of treatment with thalidomide." Spectra were taken at baseline and after 2, 5, 8 and 12weeks of treatment. Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild toModerate Melasma. Significant differences are marked in comparison to baseline (, Expert rating and selfassessment of facial skin condition. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Those products include: However, the vast majority of the products tested by Valisure contained no benzene, and dozens more contained only trace amounts of the chemical. (It shouldnt be confused with avobenzone, which is a common chemical sunscreen filter you can find on many labels.). Im curious why the kojic acid and alpha Arbutine didnt help you though. Using the Eucerin Anti-pigment night cream was a very random buy at boots pharmacy. But considering the cream is only 15 ($19), there are no safety concerns, and the other products I've tried haven't worked, I just thought "why not? . But the report and the recall dont mean youre automatically exposing yourself to a carcinogen every time you lather upor, worse yet, that you shouldn't wear SPF. Vaping cannabidiol (CBD), a compound found in marijuana, leads to more severe lung damage than vaping nicotine, according to a study out of Roswell Park Comprehensive Cancer Center. doi: 10.1111/dth.14095. Lobjectif de cette investigation tait dtudier le potentiel de ce compos pour prvenir la PIH induite par une plaie pidermique (bulle de succion) et lie lacn. They say that they replicated human Tyrosinase, and tested 50,000 chemicals on it, including the go-to skin lightening ingredients Arbutin, Kojic acid, and the infamous Hydroquinone. Bethesda, MD 20894, Web Policies Previous research has documented the effects of smoking cannabis, but . Les valuations comprenaient une valuation clinique et subjective de lhyperpigmentation, de ltat de la peau, du hmi/modifi MASI, du chromamtre et de la photographie clinique. Hoping to find some more resources then. Thiamidol versus untreated control (cell A) In cell A, 39 subjects were enrolled and 31 completed the study. Darzalex, Revlimid, Velcade, thalidomide, clofazimine, Pomalyst, Thalomid, Kyprolis, Lamprene, Ninlaro. Melanin is the brown pigment that determines the colour of our skin. Keywords: Med. Lapplication de Thiamidol quatre fois par jour, amliore lhyperpigmentation du visage de manire plus significative que deux fois par jour et est bien tolr par les sujets. Roggenkamp D, Dlova N, Mann T, Batzer J, Riedel J, Kausch M, Zoric I, Kolbe L. Int J Cosmet Sci. However, Beiersdorf researchers succeeded and were the first to isolate the human enzyme and made it available for testing. 2022 Oct 27;14(11):2308. doi: 10.3390/pharmaceutics14112308. DONATE NOW. Semin. Thiamidol was well-tolerated and well-perceived and represents an effective agent to reduce hyperpigmentation. Conclusion: Our rating: False. Arch Dermatol 135 (1999): 1079-87, 3. Med. Valisure petitioned the FDA for a recall of 40 affected batches of sunscreen, which includes all samples that had a benzene concentration of at least 0.1 ppm. From Celtic or Scandinavian ancestry. Epub 2021 Oct 21. Eucerin Anti-Pigment products contain Thiamidol and can be used alongside dermatological treatments such as chemical peels and laser therapies when skin is fully intact (and not wounded or open) to boost and extend results. * User survey after two weeks. A skin care regimen with Thiamidol significantly improved acne-related PIH over 12 weeks shown by Mexameter measurements, expert grading, self-grading and clinical photography. Last updated on Oct 27, 2022. Less melanin is transported from the basal layer of the skin to the top of the skin and with that, pigment spots gradually fade and are prevented from reappearing. Eucerins DERMOPURE range also contains a product formulated to reduce post-acne marks and prevent the appearance of blemishes. We believe in creating active ingredients and soothing formulas with high tolerability that work to help you live your life better each day. Out of 50,000 components tested, Thiamidol stood out for its ability to able to block the tyrosinase in small concentrations. Along with its needed effects, thalidomide may cause some unwanted effects. Laser therapy can also cause mild redness and irritation of the skin, but these symptoms go away shortly after treatment. Product in use test, n=130 (50-65y) with a high incidence of age spots on hands using blinded test product for two weeks at least daily. Un programme de soins de la peau contenant du Thiamidol a significativement amlior la PIH lie lacn sur 12 semaines, comme lont dmontr les mesures de Mexameter, lvaluation par des experts, lauto-valuation des sujets et la photographie mdicale. Likely to have had lots of acne or acne cysts and/or nodules. Epub 2019 Feb 27. Four-times daily Thiamidol improves facial hyperpigmentation significantly more than two-times daily and is well tolerated by the subjects. Thiamidol effectively reduces melanin production by blocking the enzyme tyrosinase, which converts the amino acid tyrosine into melanin. First results are visible . Freckles are more common on the face of red-headed, poorly pigmented individuals. . Ovarian cancer is estimated to be the third most common cancer among Indian women constituting approximately 40,000 cases being diagnosed per year. Acting at the root cause of hyperpigmentation, it works by reducing melanin production. It says after 4 weeks, the spots that were treated with Thiamidol were significantly lighter, and after 12 weeks, they were indistinguishable from the surrounding 'normal' skin. Int J Environ Res Public Health. and may cause emotional and psychological distress and reduced quality of life. Morgado-Carrasco D, Piquero-Casals J, Granger C, Trulls C, Passeron T. Photodermatol Photoimmunol Photomed. Would you like email updates of new search results? J. 20, 470481 (2018). I am looking on the Eucerin US website, and I don't see it offered there. Objective: The root cause of PiH is increased melanin production. -, McKesey, J. , TovarGarza, A. and Pandya, A.G. Melasma treatment: an evidencebased review. . Vachiramon V, Kositkuljorn C, Leerunyakul K, Chanprapaph K. J Cosmet Dermatol. ingredient Thiamidol, for which Beiersdorf enjoys patent protection in important countries around the world, is clinically proven to reduce the production . billion pound cruise Read this article to learn how you can use Eucerin products containing Thiamidol to make your skin more even. Read this article to learn how you can use Eucerin products containing Thiamidol to make your skin . Basically, it acts at the root cause of hyperpigmentation while visibly reducing dark spots over time and, when used regularly, prevents their re-appearance. Liu F, Qu L, Li H, He J, Wang L, Fang Y, Yan X, Yang Q, Peng B, Wu W, Jin L, Sun D. Pharmaceutics. Its not an ingredient in sunscreen; the contamination is more likely a result of the manufacturing process. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Neutrogena, Sun Bum, CVS Health, and Fruit of the Earth were among the brands with the highest levels of the carcinogen, per the labs results. Dermatol. (a) Representative examples of suction blisterinduced PIH treated with the Thiamidolcontaining formulation or vehicle at baseline and after 2 and 12weeks of treatment. Changes in mMASI scores during treatment with Thiamidol compared to hydroquinone in cell B. Recently, isobutylamido-thiazolyl-resorcinol (Thiamidol) was described as a very potent inhibitor of human tyrosinase. Sprays, gels, and lotions with both chemical and mineral-based formulations contained benzene, Valisure wrote. As someone who religiously uses Arbutin and Kojic acid, Im very interested in this. Neutrogenas UltraSheer Weightless Sunscreen Spray SPF 100, for example, contained the most benzene of the batches tested, with 6.26 ppm, or more than triple the FDAs limit. Thiamidol was . Really curious to hear about your experience with this product, esp as I'm based in the US and I've mainly only found this product available via EBay right now (or for 2x the price on Amazon). -. 2020 Society of Cosmetic Scientists and the Socit Franaise de Cosmtologie. These side effects may go away during treatment as your body adjusts to the medicine. Medically reviewed by Drugs.com. Cutan. Sci. J. Clin. The Washington Standard / February 28, 2023. Before I've been using Alpha Arbutin and Kojic acid twice a day for 6 months with no results, so I've been searching for something new. Popular options from brands like Banana Boat, Coppertone, Coola, EltaMD had no detectable carcinogens. Women are a bit more likely than men to get rosacea. Data are depicted as meanSD. J Clin Oncol 24 (2006): 4942-4, 11. HPV can cause cancers of the: Cervix, vagina, and vulva in women Penis external icon in men; Anus external icon in both men and women; Back of the throat, including the base of the tongue and tonsils (oropharynx), in both men and women Cancer usually takes years, even decades, to develop after a person gets HPV. Thiamidol; claim substantiation; emulsions; hyperpigmentation; skin physiology; structure. 42.00. Roggenkamp D, Sammain A, Frstenau M, Kausch M, Passeron T, Kolbe L. J Dermatol. Medical Conditions. Facial hyperpigmentation is a common skin issue that can cause embarrassment and affect the quality of life in majority of people. To summarize this effect, normal cells primarily produce energy by the consumption . It has been clinically and dermatologically proven to reduce dark spots and prevent their re-appearance. In clinical studies, it was shown to improve facial hyperpigmentation, post-inflammatory hyperpigmentation and age spots significantly. I have hyperpigmentation on some areas of my body. Seborrhoeic keratosis is a harmless warty spot that appears during adult life as a common sign of skin ageing. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Thiamidol is a new potent tyrosinase inhibitor that has been found effective as a cosmeceutical for the depigmenting of melasma. 2022. They also did a clinical study, where they compared a cream containing 0.2% Thiamidol, and a placebo cream (all the same ingredients as the first cream, just without the Thiamidol) used twice daily on age spots. Maximum quantity reached. Because of this gray area, we really dont know how much benzene is unsafe to apply to our skin or how much is present in our favorite productsespecially because the level can change from batch to batch, Valisure says. Going to keep using it until it's gone. I've been using daily to lighten some hyperpigmentation spots on my nose and forehead. Venereol. 3. Squamous cell cancer (SCC), also known as squamous cell carcinoma, is a type of cancer. Int. Epub 2021 May 21. Dermatol. Br. J Rheumatol 26 (1999): 2344-7, 9. Federal government websites often end in .gov or .mil. (liver spots) - Causes, symptoms and treatment for 'sun spots' 9 min read . Product details. Celgene Corporation (2001): 2. Its understandable to throw away any of the sunscreens cited in the report. sharing sensitive information, make sure youre on a federal Coadministration of dexamethasone increases this risk. 30ML | 140.00 per 100ML. None of the other authors state a conflict of interest. Lhyperpigmentation post-inflammatoire (Post-Inflammatory Hyperpigmentation, PIH) est une proccupation dordre esthtique majeure, en particulier chez les personnes dont le teint est plus fonc. Dermatol. An. J Cutan. Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study. The top 10 cosmeceuticals for facial hyperpigmentation. FOIA Le Thiamidol reprsente un ingrdient sr et efficace pour les produits cosmtiques contre lhyperpigmentation post-inflammatoire. Kang BY, Ibrahim SA, Shokeen D, Schlessinger DI, Kirkham JJ, Schmitt J, Poon E, Maher IA, Sobanko JF, Cartee TV, Alam M. Arch Dermatol Res. [Ref], Very common (10% or more): Hypocalcemia (95%), anorexia (28%), weight loss (23%), weight gain (22%), Common (1% to 10%): Hypokalemia, hyperlipidemia, Rare (less than 0.1%): Increased appetite, Frequency not reported: Increased appetite, electrolyte abnormalities, hyperkalemia, hypocalcemia, hypoproteinemia, increased lactate dehydrogenase (LDH), decreased phosphorus, Postmarketing reports: Tumor lysis syndrome, hypercalcemia, hyponatremia, hypomagnesemia[Ref], Very common (10% or more): Fatigue (79%), edema (56%), peripheral edema (34%), asthenia (24%), pyrexia/fever (24%), Common (1% to 10%): Accidental injury, chills, infection, pain, malaise, weakness, lethargy, Frequency not reported: Tinnitus, palpable spleen, Postmarketing reports: Sepsis, septic shock, hearing impairment/deafness, hangover effect[Ref], Very common (10% or more): Constipation (55%), nausea (28%), diarrhea (18.7%), dry mouth (12%), oral moniliasis (11.1%), dyspepsia (11%), Common (1% to 10%): Abdominal pain, vomiting, flatulence, Uncommon (0.1% to 1%): Diverticular perforation, peritonitis, Very rare (less than 0.01%): Intestinal obstruction, Frequency not reported: Enlarged abdomen, eructation, Postmarketing reports: Gastrointestinal (GI) perforation, GI hemorrhage, pancreatitis, bile duct obstruction, stomach ulcer, aphthous stomatitis[Ref], Very common (10% or more): Sensory neuropathy (54%), drowsiness/somnolence/sedation (37.5%), tremor (26%), dizziness/lightheadedness (23%), motor neuropathy (22%), headache (18.7%), depressed level of consciousness (16%), paresthesia (15.6%), sensory peripheral neuropathy (10%), Common (1% to 10%): Cerebrovascular accident/event, syncope, vertigo, abnormal coordination, transient ischemic event, ataxia, amnesia, causalgia, circumoral paresthesia, hyperesthesia, dysesthesia, Frequency not reported: Neuritis, peripheral neuritis, neuralgia, hypertonia, Postmarketing reports: Seizures, convulsions, Parkinson's disease/worsening of Parkinson's disease symptoms, posterior reversible encephalopathy syndrome (PRES)/reversible posterior leukoencephalopathy syndrome (RPLS), stupor, stroke, carpal tunnel, Raynaud's syndrome, migraine, foot drop[Ref], Very common (10% or more): Neutropenia (42.7%), decreased leukocytes (35%), decreased neutrophils (31%), leukopenia (25.8%), anemia (13.7%), lymphadenopathy (12.5%), lymphopenia (12.1%), thrombocytopenia (11.3%), Very rare (less than 0.01%): Eosinophilia, Frequency not reported: Increased/decreased platelet count, decreased erythrocyte sedimentation rate (ESR), granulocytopenia, hypochromic anemia, leukocytosis, elevated mean corpuscular volume (MCV), abnormal red blood cell (RBC) count, Postmarketing reports: Febrile neutropenia, pancytopenia, decreased white blood cell (WBC) count, prothrombin time changes, lymphedema[Ref], Very common (10% or more): Dyspnea (42%), pneumonia (15%), Common (1% to 10%): Bronchopneumonia, pulmonary embolism, pharyngitis, sinusitis, interstitial lung disease, Very rare (less than 0.01%): Bronchospasm, Frequency not reported: Cough, emphysema, epistaxis, rales, upper respiratory infection, voice alteration[Ref], Very common (10% or more): Muscle weakness (40%), myalgia (17%), arthralgia (13%), Frequency not reported: Upper extremity pain, arthritis, bone tenderness, joint disorder, leg cramps, myasthenia, periosteal disorder[Ref], Very common (10% or more): Rash/desquamation (30%), rash (25%), dry skin (21%), maculopapular rash (18.7%), sweating (12.5%), acne (11.1%), Common (1% to 10%): Fungal dermatitis, nail disorder, pruritus, toxic skin eruption, urticaria, Very rare (less than 0.01%): Severe skin reactions (Stevens-Johnson Syndrome, toxic epidermal necrolysis), facial edema, photosensitivity, alopecia, eczematous rash, exfoliative dermatitis, ichthyosis, perifollicular thickening, skin necrosis, seborrhea, sweating, vesiculobullous rash, Postmarketing reports: Erythema multiforme, erythema nodosum, purpura, petechiae[Ref], Very common (10% or more): Confusion (28%), anxiety/agitation (26%), depression (10%), Common (1% to 10%): Insomnia, nervousness, abnormal thinking, euphoria, impotence, altered mood/mood changes/mental status changes, Very rare (less than 0.01%): Decreased libido, Postmarketing reports: Sexual dysfunction, suicide attempts[Ref], Very common (10% or more): Thrombosis/embolism (22%), deep vein thrombosis (13%), Common (1% to 10%): Atrial fibrillation, myocardial ischemia/infarction, bradycardia, cardiac failure, hypotension, Uncommon (0.1% to 1%): Orthostatic hypotension, Rare (less than 0.1%): Tachycardia, cardiac arrhythmia, Frequency not reported: Hypertension, peripheral vascular disorder, vasodilation, cyanosis, Postmarketing reports: Atrioventricular block, pulmonary hypertension, sick sinus syndrome, electrocardiogram (ECG) abnormalities[Ref], Very common (10% or more): Hyperglycemia (15%), Very rare (less than 0.01%): Hypothyroidism, menstruation abnormalities, amenorrhea, Frequency not reported: Diabetes, inappropriate antidiuretic hormone (ADH), Postmarketing reports: Myxedema, galactorrhea, gynecomastia[Ref], Very common (10% or more): Abnormal bilirubin level (14%), increased SGOT (12.5%), Common (1% to 10%): Abnormal liver function tests, Frequency not reported: Enlarged liver, bilirubinemia, increased SGPT, Postmarketing reports: Increased alkaline phosphatase[Ref], Very common (10% or more): Hematuria (11.1%), Frequency not reported: Hyperuricemia, proteinuria, pyuria, urinary frequency, orchitis, Postmarketing reports: Oliguria, enuresis, metrorrhagia[Ref], Frequency not reported: Amblyopia, dry eye, eye pain, Postmarketing reports: Diplopia, nystagmus[Ref], Frequency not reported: Hypersensitivity/allergic reactions, angioedema[Ref], Frequency not reported: Viral reactivation (herpes zoster, hepatitis B, cytomegalovirus), increased HIV viral load/RNA levels, amyloidosis, Postmarketing reports: Viral infections[Ref], Frequency not reported: Acute myeloid leukemia, myelodysplastic syndromes, Postmarketing reports: Chronic myelogenous leukemia, nodular sclerosing Hodgkin's disease, erythroleukemia[Ref], Frequency not reported: Increased BUN, increased creatinine, Postmarketing reports: Renal failure, acute renal failure[Ref]. 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